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Frontostriatal circuit
Frontostriatal circuits are neural pathways that connect frontal lobe regions with the basal ganglia (striatum) that mediate motor, cognitive, and behavioural functions within the brain. They receive inputs from dopaminergic, serotonergic, noradrenergic, and cholinergic cell groups that modulate information processing. Frontostriatal circuits are part of the executive functions. Executive functions includes following: selection and perception of important information, manipulation of information in working memory, planning and organization, behavioral control, adaptation to changes, and decision making. These circuits are involved in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease as well as neuropsychiatric disorders including schizophrenia, depression, obsessive compulsive disorder (OCD), and attention-deficit hyperactivity disorder (ADHD).〔
==Anatomy==
There are five defined frontostriatal circuits: motor and oculomotor circuits originating in the frontal eye fields are involved in motor functions; while dorsolateral prefrontal, orbital frontal, and anterior cingulate circuits are involved in executive functions, social behavior and motivational states. These five circuits share same anatomical structures. These circuits originate in prefrontal cortex and project to the striatum followed by globus pallidus and substantia nigra and finally to the thalamus.〔 There are also feedback loops from thalamus back to prefrontal cortex completing the closed loop circuits. Also, there are open connections to these circuits integrating information from other areas of the brain.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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